Journal
CELLULAR AND MOLECULAR LIFE SCIENCES
Volume 57, Issue 4, Pages 604-611Publisher
BIRKHAUSER VERLAG AG
DOI: 10.1007/PL00000722
Keywords
Ras/MAPK signalling; synaptic plasticity; learning and memory; hippocampus
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Funding
- Telethon [E.0655] Funding Source: Medline
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Ras-related guanosine triphosphatases (GTPases) couple receptor activity to a number of intracellular signalling events culminating in the control of cell morphology and gene transcription. In culture cells, the best-understood Ras-dependent signalling pathway involves the mitogen-activated protein kinase/extracellular-regulated kinase (MAPK/ERK) cascade. A growing body of evidence has recently been accumulating to suggest a crucial role of Ras and MAPK signalling in neuronal functions connected to synaptic plasticity. In the present review article we discuss the experimental basis supporting the notion that the Ras/MAPK pathway interacts with other synaptic mechanisms to regulate invertebrate and vertebrate behavioural responses such as those implicated in learning and memory processes.
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