Journal
BIOMATERIALS
Volume 31, Issue 15, Pages 4304-4312Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.biomaterials.2010.01.145
Keywords
Poly (1,8 Octanediol-co-Citrate) (POC); Poly (glycerol sebacate) (PGS); Polycaprolactone (PCL); Chondrogenesis; Controlled scaffold tissue engineering
Funding
- NIH [R01 AR 053379]
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The goal of this study was to determine material effects on cartilage regeneration for scaffolds with the same controlled architecture. The 3D polycaprolactone (PCL), poly (glycerol sebacate) (PGS), and poly (1,8 octanediol-co-citrate) (POC) scaffolds of the same design were physically characterized and tissue regeneration in terms of cell phenotype, cellular proliferation and differentiation, and matrix production were compared to find which material would be most optimal for cartilage regeneration in vitro. POC provided the best support for cartilage regeneration in terms of tissue ingrowth, matrix production, and relative mRNA expressions for chondrocyte differentiation (Col2/Col1). PGS was seen as the least favorable material for cartilage based on its relatively high de-differentiation (Col1), hypertrophic mRNA expression (Col10) and high matrix degradation (MMP13, MMP3) results. PCL still provided microenvironments suitable for cells to be active yet it seemed to cause de-differentiation (Coll) of chondrocytes inside the scaffold while many cells migrated out, growing cartilage outside the scaffold. (C) 2010 Elsevier Ltd. All rights reserved.
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