Journal
CARBOHYDRATE POLYMERS
Volume 41, Issue 4, Pages 389-396Publisher
ELSEVIER SCI LTD
DOI: 10.1016/S0144-8617(99)00104-6
Keywords
chitosan; glutaraldehyde; gelation kinetics; chain-relaxation; microsphere; drug-release
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The effects of gelation kinetics and chain-relaxation properties of glutaraldehyde-cross-linked chitosan gel on microspheres preparation or drug release were studied. The rate of gelation is zero order corresponding to the chitosan concentration but non-zero order corresponding to the glutaraldehyde concentration. It was suggested that the cross-linking reaction was mainly dominated by the concentration of small molecule reactant, glutaraldehyde. The relaxation of an entangled polymer chain in a gel network as a result of the swelling of cross-linked chitosan hydrogel was investigated by the stress-strain determination. The higher the cross-linking density of chitosan hydrogel, the lower the swelling ability of chitosan hydrogel due to the slower relaxation rate of polymer chain, which then results in the decreased drug-release rate. (C) 2000 Elsevier Science Ltd. All rights reserved.
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