4.4 Article

mRNA stability in eukaryotes

Journal

CURRENT OPINION IN GENETICS & DEVELOPMENT
Volume 10, Issue 2, Pages 193-198

Publisher

CURRENT BIOLOGY LTD
DOI: 10.1016/S0959-437X(00)00063-0

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During the past two years, the role of the proteins HuR and hnRNP D in regulated mRNA degradation in humans has become clearer, and a putative mRNA deadenylase, DAN or PARN, has been identified. In yeast, the relationship between translation and mRNA turnover is clearer, but the mRNA decapping process has turned out to be unexpectedly complex.

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