Journal
BIOMATERIALS
Volume 31, Issue 15, Pages 4278-4285Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.biomaterials.2010.01.059
Keywords
PLGA; PHBV; Scaffold; Bone repair; Microsphere; Tissue engineering
Funding
- National Natural Science Foundation of China [50572029, 50732003]
- Natural Science Foundation of Guangdong [4305786]
- National Basic Research program of China [2005 CB623902]
- National Key Technologies RD Program [2006BA116B04]
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Polymer scaffolds, particularly in the form of microspheres, have been employed to support cells growth and deliver drugs or growth factors in tissue engineering. In this study, we have established a scaffold by embedding poly (beta-hydroxybutyrate-co-beta-hydroxyvalerate) (PHBV) microspheres into poly (L-lactic-coglycolic acid) (PLGA) matrix, according to their different solubility in acetone, with the aim of repairing bone defects. PLGA/PHBV scaffolds had good pore parameters, for example, the porosity of PLGA/30% PHBV scaffold can reach to 81.273 +/- 2.192%. Besides, the pore size distribution of the model was evaluated and the results revealed that the pore size mainly distributed between 50 mu m and 200 mu m. With increasing the amount of PHBV microspheres, the compressive strength of the PLGA/PHBV scaffold enhanced. The morphology of the hybrid scaffold was rougher than that of pure PLGA scaffold, which had no significant effect on the cell behavior. The in vitro evaluation suggested that the model is suitable as a scaffold for engineering bone tissue, and has the potential for further applications in drug delivery system. (C) 2010 Elsevier Ltd. All rights reserved.
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