Journal
JOURNAL OF INORGANIC BIOCHEMISTRY
Volume 79, Issue 1-4, Pages 261-265Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/S0162-0134(99)00179-8
Keywords
heavy metal mutagenicity; bioinorganic model chemistry
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The mutagenicity of metal species may be the result of a direct interaction with the target molecule DNA. Possible scenarios leading to nucleobase mispairing are discussed, and selected examples are presented. They include changes in nucleobase selectivity as a consequence of alterations in acid-base properties of nucleobase atoms and groups involved in complementary H bond formation, guanine deprotonation, and stabilization of rare nucleobase tautomers by metal ions. Oxidative nucleobase damage brought about by metal species will not be considered. (C) 2000 Elsevier Science Inc. All rights reserved.
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