Journal
BIOMATERIALS
Volume 30, Issue 29, Pages 5617-5621Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.biomaterials.2009.06.036
Keywords
Zwitterionic; Poly(carboxybetaine); Functionalization; Undiluted blood serum
Funding
- National Science Foundation [DMR-0705907]
- Office of Naval Research [N000140910137]
- China Scholarship Council
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A new surface chemistry presenting an abundance of functional groups for ligand immobilization in an ultra-low fouling background all in one material for nanoparticles was introduced. This surface platform, as demonstrated by zwitterionic poly(carboxybetaine acrylamide) (polyCBAA) coated nanoparticles, is not only ultra stable in undiluted human blood serum, but also can be conjugated to biomolecules conveniently and effectively. Thus, this surface chemistry is ideal to create multi-functional nanoparticles for targeted delivery and diagnostics. In addition, this work clearly shows that 10% blood serum commonly used to evaluate the stability of nanoparticles is insufficient and a new evaluation criterion with undiluted blood serum is recommended. Published by Elsevier Ltd.
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