Journal
FITOTERAPIA
Volume 71, Issue 2, Pages 147-153Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/S0367-326X(99)00132-X
Keywords
premna herbacea; antipyretic activity; antinociceptive activity; anti-inflammatory activity
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The alcoholic extract of the roots of Premna herbacea was investigated for its antipyretic, antinociceptive and anti-inflammatory potential in animal models. The extract, when administered orally to mice has been found to be safe up to a dose of 8.0 g/kg. A significant antipyretic effect has been observed in rabbits while mild antinociceptive effects were evidenced in mice when tested by chemical as well as thermal methods. The extract did not exhibit any anti-inflammatory activity in acute but significantly reduced the chronic inflammation. (C) 2000 Elsevier Science B.V. All rights reserved.
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