Journal
BIOMATERIALS
Volume 30, Issue 28, Pages 5077-5085Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.biomaterials.2009.05.082
Keywords
Hemoglobin; Artificial oxygen carrier; Red blood cells; Micelles
Funding
- National Natural Science Foundation of China [20674084, 20774093]
- National Fund for Distinguished Young Scholars [50425309]
- Ministry of Science and Technology of China [2009CB930102]
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An artificial oxygen carrier is constructed by conjugating hemoglobin molecules to biodegradable micelles. Firstly a series of triblock copolymers (PEG-PMPC-PLA) in which the middle block contains pendant propargyl groups were synthesized and characterized. After the amphiphilic copolymer was self-assembled into core-shell micelles in aqueous solution, azidized hemoglobin molecules protected by carbon monoxide (CO) were conjugated to the micelles via click reaction between the propargyl and azido groups. The conjugation causes an increase of the micelle's mean diameter. Maximum conjugation ratio is 250 wt% in the hemoglobin-conjugated micelles (HCMs). Oxygen-binding ability of the HCMs was demonstrated by converting the CO-binding state of the HCMs into O-2-binding state. (C) 2009 Elsevier Ltd. All rights reserved.
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