Journal
BIOMATERIALS
Volume 30, Issue 8, Pages 1657-1664Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.biomaterials.2008.12.002
Keywords
Polyanhydride; Polyorthoester; Biodegradation; Controlled drug release; Modeling
Funding
- NCATS NIH HHS [KL2 TR000146] Funding Source: Medline
- NCRR NIH HHS [KL2 RR024154, KL2 RR024154-04] Funding Source: Medline
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A unified model has been developed to predict release not only from bulk eroding and Surface eroding systems but also from matrices that transition from suface eroding to bulk eroding behavior during the Course of degradation. This broad applicability is afforded by fundamental diffusion/reaction equations that can describe a wide variety of scenarios including hydration of and mass loss from a hydrolysable polymer matrix. Together, these equations naturally account for spatial distributions of polymer degradation rate. In this model paradigm, the theoretical minimal size required for a matrix to exhibit degradation under Surface eroding conditions was calculated for Various polymer types and then verified by empirical data from the literature. An additional Set Of equations accounts for dissolution and/or degradation-based release, which are dependent upon hydration of the matrix and erosion of the polymer. To test the model's accuracy, predictions for agent egress were compared to experimental data from polyanhydride and polyorthoester implants that were postulated to undergo either dissolution-limited or degradation-con trolled release. Because these predictions are calculated solely from readily attainable design parameters, it seems likely that this model could be Used to guide the design controlled release formulations that produce a broad array Of custom release profiles. (C) 2008 Elsevier Ltd. All rights reserved.
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