Journal
BIOMATERIALS
Volume 30, Issue 30, Pages 5999-6005Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.biomaterials.2009.07.047
Keywords
Biosensor; Nanocomposite; Silica; Immobilization; Glucose oxidase
Funding
- Kyungpook National University Research Fund [KOSEF-2008-05994]
- Korean Research Foundation [KRF-2006-C00001]
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A glucose biosensor was fabricated with loading of glucose oxidase (GOx) into a new organic-inorganic hybrid nanocomposite. The preparation involves formation of silica network into a Nafion (per-fluorosulfonate ionomer) and subsequent loading of polyaniline grafted multiwalled carbon nanotubes (MWNT-g-PANI) onto Nafion-silica nanocomposite. Field emission scanning electron microscopy (FE-SEM) of Nafion-silica/MWNT-g-PANI composite reveals the presence of spherical silica particles (sizes in the range 250 nm-1 mu m) and tubular MWNT-g-PANI particles. Chronoamperometry and cyclic voltammetry were used to evaluate the performance of biosensor towards glucose. The Nafion-silica/MWCNT-g-PANI/GOx biosensor exhibited a linear response to glucose in the concentration range of 110 mm with a correlation coefficient of 0.9972, good sensitivity (5.01 mu A/mM), a low response time (similar to 6 s), repeatability (R.S.D value of 2.2%) and along-term stability. The presence of silica network within Nafion and MWNT-g-PANI synergistically contributes to the performance of the biosensor towards the electrochemical detection of glucose. (C) 2009 Elsevier Ltd. All rights reserved.
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