Journal
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
Volume 11, Issue 2, Pages 67-76Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1006/scdb.2000.0153
Keywords
implantation; uterus; blastocyst; mouse; HB-EGF; COX-2; PPAR delta
Categories
Funding
- NICHD NIH HHS [HD 29968, HD 12304, HD 33994] Funding Source: Medline
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Successful implantation is the result of an. intimate 'cross-talk' between the blastocyst and uterus in a temporal and cell-specific manner: Thus, both the uterine and embryonic events must be examined to better understand this process. Although various aspects and molecules associated with these events have been explored, a comprehensive understanding of the implantation process is still very limited. In this review we have highlighted the importance of the blastocyst's activity state and the receptive state of the uterus in determining the 'window' of implantation. In this context, we provide a testable scheme that signifies the important roles of various key molecules in embryo-uterine interactions during implantation. (C) 2000 Academic Press.
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