Journal
BIOMATERIALS
Volume 30, Issue 33, Pages 6479-6484Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.biomaterials.2009.08.021
Keywords
Biopolymer; Soft tissue engineering; Polyester; Shape memory; Smart polymers
Funding
- NIH [T90 DK070071]
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In this paper we describe the mechanical and biological features of a thermosetting polyester synthesized from glycerol and dodecanedioic acid named Poly-Glycerol-Dodecanoate (PGD). This polymer shows a glass transition temperature (T-g) around 32 degrees C, and this accounts for its mechanical properties. At room temperature (21 degrees) PGD behaves like a stiff elastic-plastic material, while at body temperature (37 degrees C), it shows a compliant non-linear elastic behavior. Together with biodegradability and biocompatibility PGD has distinct shape memory features. After the polymer is cured, no matter what the final configuration is, we can recover the original shape by heating PGD to temperatures of 32 degrees C and higher. The mechanical properties together with biocompatibility/biodegradability and shape memory features make PGD an attractive polymer for biomedical applications. (C) 2009 Elsevier Ltd. All rights reserved.
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