Journal
BIOMATERIALS
Volume 30, Issue 23-24, Pages 3978-3985Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.biomaterials.2009.04.004
Keywords
Nitric oxide; NO-releasing vaginal film; Female sexual arousal disorder; Vagina blood flow
Funding
- Missouri Life Science Research Board [09-119]
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Nitric oxide (NO)-releasing vaginal films were developed and evaluated as a potential advanced treatment option for female sexual arousal disorder (FSAD). The polymeric films containing s-nitrosoglutathione (GSNO), an endogenous NO donor, were prepared using the reduced-pressure drying method. The surface morphology, thermal/mechanical properties, stability, loading efficiency and physicodynamic properties were characterized and the pharmacological activities were evaluated through in vitro and in vivo studies. The GSNO films were homogeneous and transparent, and showed suitable mucoadhesiveness and mechanical properties. The release profiles of NO from the GSNO films followed the first-order kinetic pattern and NO activated the NO-cGMP signaling pathway in vaginal cells. The GSNO films significantly enhanced the duration of action of GSNO and vagina blood perfusion in the rat model without causing any cytotoxic effects. The NO-releasing vaginal films might be used as a promising treatment device against FSAD. Published by Elsevier Ltd.
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