Journal
BIOMATERIALS
Volume 30, Issue 2, Pages 160-168Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.biomaterials.2008.09.026
Keywords
Foreign body response; Cytokine; Cage implant; Inflammation; Wound healing; Biomaterial
Funding
- National Institutes of Health (NIH) [DK54932]
- National Science Foundation Graduate Research Fellowship
- NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES [R56DK054932, R01DK054932] Funding Source: NIH RePORTER
Ask authors/readers for more resources
Cytokines, chemokines, and growth factors were analyzed periodically over eight weeks from the wound exudate fluid surrounding biomaterials implanted subcutaneously within stainless steel mesh cages. TNF-alpha, MCP-1, MIP-1 alpha, IL-2, IL-6, IL-15, VEGF, IL-4, and IL-10 were measured from exudate samples collected from cages containing specimens of polyethylene (PE), polyurethane (PU), or organotin polyvinyl chloride (ot-PVC). Empty cages served as negative controls, and lipopolysaccharide (LPS) served as a positive control. Cytokine, chemokine, and growth factor concentrations decreased from the time of implantation to eight weeks post-implantation, and there was an overall increase in cytokine, chemokine, and growth factor production for material-containing cages compared to empty cages. However, cytokine production was only modestly affected by the different Surface chemistries of the three implanted polymeric materials. (c) 2008 Elsevier Ltd. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available