Journal
BIOMATERIALS
Volume 30, Issue 7, Pages 1363-1371Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.biomaterials.2008.11.027
Keywords
Galactosylated micelle; Liver targeting; Controlled release
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Galactosylated and fluroscein isothiocyanate (FITC) labeled polycaprolactone-g-dextrin (Gal-PCL-g-Dex-FITC) polymers were synthesized. The grafted polymers can self-assemble into stable micelles in aqueous medium and in serum. Transmission electron microscopy (TEM) images showed that the self-assembled micelles were regularly spherical in shape. Micelle size determined by size analysis was around 120 nm. The anti-inflammation drug prednisone acetate as a model drug was loaded in the polymeric micelles, and the in vitro drug release was investigated. The galactosylated micelles could be selectively recognized by HepG2 cells anti subsequently accumulate in HepG2 cells. The in vivo study demonstrated the relative uptake of the micelles by liver is much higher than the other tissues, indicating that the galactosylated micelles have great potential as a liver targeting drug carrier. (c) 2008 Elsevier Ltd. All rights reserved.
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