Journal
INFECTION AND IMMUNITY
Volume 68, Issue 4, Pages 2366-2368Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/IAI.68.4.2366-2368.2000
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Funding
- NHLBI NIH HHS [HL36611, R01 HL036611] Funding Source: Medline
- NIGMS NIH HHS [GM08277, GM54384, T32 GM008277] Funding Source: Medline
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The staphylococcal exfoliative toxins (ETs) A and B (ETA and ETB) are 27-kDa exotoxins produced by certain strains of Staphylococcus aureus and are the causative agents of staphylococcal scalded-skin syndrome. The crystal structures of the ETs strongly indicate that the proteins are members of the serine protease family of enzymes, although protease activity until now has not yet been conclusively demonstrated. Here, we show that the peptide beta-melanocyte-stimulating hormone (beta-MSH) is cleaved by ETA and that both ETA and ETB are capable of cleaving alpha-MSH. Both toxins exhibit cleavage at specific glutamic acid residues in MSH peptides. Moreover, biologically inactive mutants of ETA were incapable of cleaving beta-MSH.
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