Journal
BIOMATERIALS
Volume 29, Issue 10, Pages 1526-1532Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.biomaterials.2007.11.025
Keywords
DNA; silica; surface modification; confocal microscopy; cell viability; drug delivery
Funding
- NIBIB NIH HHS [R0I EB000244] Funding Source: Medline
Ask authors/readers for more resources
Highly fluorescent core-shell silica nanoparticles made by the modified Stober process (C dots) are promising as tools for sensing and imaging subcellular agents and structures but will only be useful if they can be easily delivered to the cytoplasm of the subject cells. This work shows that C dots can be electrostatically coated with cationic polymers, changing their surface charge and enabling them to escape from endosomes and enter the cytoplasm and nucleus. As an example of cellular delivery, we demonstrate that these particles can also be complexed with DNA and mediate and trace DNA delivery and gene expression. (c) 2007 Published by Elsevier Ltd.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available