Journal
TRANSGENIC RESEARCH
Volume 9, Issue 2, Pages 127-135Publisher
KLUWER ACADEMIC PUBL
DOI: 10.1023/A:1008979525909
Keywords
edible vaccine; immunoglobulins G and A; respiratory syncytial virus; transgenic tomato
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Respiratory syncytial virus (RSV) is one of the most important pathogens of infancy and early childhood. Here a fruit-based edible subunit vaccine against RSV was developed by expressing the RSV fusion (F) protein gene in transgenic tomato plants. The F-gene was expressed in ripening tomato fruit under the control of the fruit-specific E8 promoter. Oral immunization of mice with ripe transgenic tomato fruits led to the induction of both serum and mucosal RSV-F specific antibodies. The ratio of immunoglobulin subclasses produced in response to immunization suggested that a type 1 T-helper cell immune response was preferentially induced. Serum antibodies showed an increased titer when the immunized mice were exposed to inactivated RSV antigen.
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