Journal
ADDICTION BIOLOGY
Volume 5, Issue 2, Pages 167-172Publisher
CARFAX PUBLISHING
DOI: 10.1080/13556210050003757
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Our study tested whether an association of the 861C allele of the serotonin 5-HT1B gene (HTR1B) with antisocial alcoholism exists in the German population. The HTP1B G861C polymorphism was genotyped in 588 subjects of German descent, comprising 250 non-alcoholic controls and 338 alcohol-dependent subjects, of whom 56 exhibited a dissocial personality disorder (DSPD). The Tridimensional Personality Questionnaire was assessed in 109 alcohol-dependent males to explore an effect of the 861C allele to risk-taking behaviour. Our results revealed no evidence for an association of the 861C allele with antisocial alcoholism (p > 0.63). There were no significant differences in the personality traits, novelty-seeking, harm avoidance and reward dependence between 46 male alcoholics carrying the 861C allele compared to those 63 alcoholics lacking it (p > 0.52). Our results do not provide evidence that the 861C allele contributes a substantial vulnerability effect to antisocial behavior in German alcohol-dependent subjects.
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