Journal
SEMINARS IN IMMUNOLOGY
Volume 12, Issue 2, Pages 139-147Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1006/smim.2000.0216
Keywords
ITAM; ITIM; kinases; phosphatases
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Despite the absence of antigen-specific receptors at their surface, NK cells can selectively eliminate virus-infected cells, tumor cells and allogenic cells. A dynamic and Precisely coordinated balance between activating and inhibitory receptors governs NK cell activation programs. Multiple activating and inhibitory NK cell surface molecules have been described, a group of them acting as receptors for MHC class I molecules. In spite of their heterogeneity, activating NK cell receptors present remarkable structural and functional homologies with T cell- and B cell-antigen receptors. Inhibitory NK cell receptors operate at early stages of activating cascades by recruiting protein tyrosine phosphatases via intracytoplasmic motifs (ITIM), a strategy which is widely conserved in hematopoietic and non-hematopoietic cells. (C) 2000 Academic Press.
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