Journal
BLOOD CELLS MOLECULES AND DISEASES
Volume 26, Issue 2, Pages 155-162Publisher
ACADEMIC PRESS INC
DOI: 10.1006/bcmd.2000.0291
Keywords
hemochromatosis; mRNA; splice variant; differential polyadenylation
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The MHC class I-related HFE gene appears to be involved in iron metabolism, but its pathogenic mechanism in hemochromatosis remains unknown. Furthermore, very little is known about the regulation of its expression. Hybridization of human tissue Northern blots revealed five different HFE mRNAs, indicating that HFE gene transcription is subject to alternative processes, cDNA selection and RT-PCR performed on HeLa cells clearly demonstrated the occurrence of either differential termination or splicing in HFE transcription. Among the numerous molecules identified, two may have a genuine biological significance. (C) 2000 Academic Press.
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