Soluble cytokine levels correlate with the activity and clinical stage of Hodgkin's disease at diagnosis

The serum levels of some cytokines seem to correlate with outcome in Hodgkin's disease (HD) and may be helpful in formulating new and better prognostic systems. The aim of this study was to analyse the correlations between the serum levels of different cytokines and the clinico-hematological features suggestive of a worse prognosis. The study involved 31 pts with a de novo diagnosis of HD (median age: 30 yrs; M/F: 13/18; stage I/II vs III/IV: 19/12; B symptoms: 12; bulky disease and extranodal disease: 9). The serum levels of sCD30, TNF alpha, TNF receptor I and II, IL6, IL6 receptor, IL10, sICAM-1 were evaluated at diagnosis, and correlated with gender, age (less than or equal to/>30), stage (I-II vs III-IV), systemic symptoms, bulky disease, ESR ( 170 mu g/dL), WBC counts (less than or equal to/> 15x10(9)/L), prognostic scores (PS) according to Hasenclever (33.15 U/mL, TNF alpha >29.71 pg/mL, IL6 >12.43 pg/mL, TNF-RI >3.23 ng/mL, IL6-R >57 ng/mL) that significantly correlate with systemic symptoms, higher disease stages, ESR, serum copper, WBC counts and PS. Our study shows that high sCD30, TNFa, IL6 and TNF-RI levels are associated with advanced disease or a worse prognostic score. In the context of multiparametric HD staging, cytokine evaluation may be useful for identifying candidates for more intensive therapies.