Journal
CRITICAL CARE MEDICINE
Volume 28, Issue 4, Pages 929-934Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/00003246-200004000-00003
Keywords
inflammation; cytokines; brain injury; pediatric; chemokines; interleukin-8; mortality; shaken baby syndrome
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Funding
- NINDS NIH HHS [NS30318] Funding Source: Medline
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Objective: To determine interleukin (IL)-8 concentrations in ventricular cerebrospinal fluid from children with severe traumatic brain injury (TBI), Design: Prospective study. Setting: University children's hospital. Patients: Twenty-seven children hospitalized with severe TBI (Glasgow Coma Scale score less than or equal to 8), seven children with cerebrospinal fluid culture-positive bacterial meningitis, and twenty-four age-equivalent controls. Interventions: Placement of an intraventricular catheter and continuous drainage of cerebrospinal fluid. Measurements and Main Results: Median [range] cerebrospinal fluid IL-8 concentration in children with TBI (0-12 hrs) (4,452.5 [0-20,000] pg/mL) was markedly greater than that in controls (14.5 [0-250]) (p <.0001) and equivalent to concentrations in children with meningitis (5,300 [1,510-22,000] pg/mL) (p =.33), Cerebrospinal fluid IL-8 remained increased in children with severe TBI for up to 108 hrs after injury, Univariate logistic regression analysis demonstrated an association between cerebrospinal fluid IL-8 and child abuse (p =.07) and mortality (p =.01), Multivariate analysis demonstrated a strong, independent association between cerebrospinal fluid IL-8 and mortality (p =.01), Conclusions: The data are consistent with an acute inflammatory component of TBI in children and suggest an association between cerebrospinal fluid IL-8 and outcome after TBI, IL-8 may represent a potential target for anti-inflammatory therapy.
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