Journal
CANCER LETTERS
Volume 151, Issue 1, Pages 49-56Publisher
ELSEVIER SCI IRELAND LTD
DOI: 10.1016/S0304-3835(99)00404-8
Keywords
transcriptional factor NF-kappa B; differentiation; thiol redox status; constitutive H2O2 generation
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Funding
- NIEHS NIH HHS [ESO3245] Funding Source: Medline
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We report herein a novel finding that under an unstimulated condition, a group of four human hepatocellular carcinoma (HCC) cell lines with varying degrees of differentiation, can spontaneously activate NF-kappa B. The propensity of activation coincided inversely with the differentiation status, with order being SK-Hep-1 > J5 > Hep3B > HepG2. Further studies indicate that this pattern of activation correlates excellently with the descending order of intracellular GSH/GSSG ratios as well as with the ascending order in the ability of these cells to generate hydrogen peroxide. Taken together, our data suggest that differentiation status may play a pivotal role in modulating intracellular thiol redox status and the extent of catalase expression, which may be crucial in the control of NF-kappa B activity in these HCC cells. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.
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