Journal
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Volume 10, Issue 7, Pages 615-617Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/S0960-894X(00)00065-2
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We have developed a novel class of cdc25A inhibitors by drastic modification of the hydrophobic and hydrophilic substructures of dysidiolide, The unsaturated derivative 3b strongly inhibited cdc25A (IC50 = 7.7 mu M) and caused G1 arrest of HL60 cells. (C) 2000 Elsevier Science Ltd. All rights reserved.
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