Protein folding: Versatility of the cytosolic chaperonin TRIC/CCT

Efficient de novo folding of actins and tubulins requires two molecular chaperones, the chaperonin TRiC (or CCT) and its novel cofactor GimC (or prefoldin). Recent studies indicate that TRiC is exquisitely adapted for this task, yet has the ability to interact with and assist the folding of numerous other cellular proteins. (C) 2000 Elsevier Science Ltd. All rights reserved.