Journal
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
Volume 1474, Issue 2, Pages 115-127Publisher
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DOI: 10.1016/S0304-4165(00)00016-7
Keywords
glycosaminoglycan; sulfotransferase; cloning; substrate specificity; function
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Sulfate residues attached to the specific position of the component sugar residues of glycosaminoglycans play important roles in the formation of functional domain structures. The introduction of a sulfate group is catalyzed by various sulfotransferases with strict substrate specificities. A rapid development achieved in the cloning of various glycosaminoglycan sulfotransferases has allowed us to study the biological functions of glycosaminoglycan sulfotransferases and their products, sulfated glycosaminoglycans. (C) 2000 Elsevier Science B.V. All rights reserved.
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