Journal
NEUROREPORT
Volume 11, Issue 5, Pages 1051-1055Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/00001756-200004070-00030
Keywords
CaMKII; hippocampus; olfaction; ontogeny; spatial learning
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Spatial learning and memory involves the ability to encode geometric relationships between perceived cues and depends critically on the hippocampus. Visually guided spatial learning has been demonstrated in adult animals. As infant animals rely heavily on olfaction, olfactory based spatial learning was assessed in infant mice. When 12-day-old pups were displaced from their nest, they learned within a few training trials to use the spatial pattern of odor cues to move back to the nest. However, mouse pups that over-expressed Ca2+/calmodulin-dependent protein kinase (CaMKII) in hippocampal neurons were impaired in olfactory based spatial learning. NeuroReport 11:1051-1055 (C) 2000 Lippincott Williams & Wilkins.
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