Journal
SCIENCE
Volume 288, Issue 5463, Pages 136-140Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.288.5463.136
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Funding
- NHLBI NIH HHS [HL56385] Funding Source: Medline
- NIAID NIH HHS [AI30663] Funding Source: Medline
- NIGMS NIH HHS [GM-5748202] Funding Source: Medline
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Long-range regulatory elements are difficult to discover experimentally; how-ever, they tend to be conserved among mammals, suggesting that cross-species sequence comparisons should identify them. To search for regulatory sequences, we examined about 1 megabase of orthologous human and mouse sequences for conserved noncoding elements with greater than or equal to 70% identity over at Least 100 base pairs. Ninety noncoding sequences meeting these criteria were discovered, and the analysis of 15 of these elements found that about 70% were conserved across mammals. Characterization of the Largest element in yeast artificial chromosome transgenic mice revealed it to be a coordinate regulator of three genes, interleukin-4, interleukin-13, and interleukin-5, spread over 120 kilobases.
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