Journal
FEBS LETTERS
Volume 471, Issue 1, Pages 119-124Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/S0014-5793(00)01372-7
Keywords
peroxisome proliferator-activated receptor; activation; osteoblast maturation; osteoporosis; thiazolidinedione
Funding
- NHLBI NIH HHS [HL30568] Funding Source: Medline
- NIA NIH HHS [AG10415] Funding Source: Medline
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The reduced bone mineral density (BMD) observed in osteoporosis results, in part, from reduced activity of bone-forming osteoblasts, We examined the effect of peroxisome proliferator-activated receptor (PPAR) activators on MC3T3-E1 preosteoblast maturation. Activators of PPAR alpha, delta and gamma induced alkaline phosphatase activity, matrix calcification and the expression of osteoblast genes as determined by reverse transcriptase-polymerase chain reaction, Howe, er, at relatively high concentrations of the specific PPAR gamma ligands, ciglitazone and troglitazone, maturation was inhibited. PPAR alpha, delta and gamma 1 were expressed in MC3T3-E1 cells. PPAR gamma 1 mRNA and protein levels were induced early during osteoblastic maturation, We speculate that endogenous and pharmacological PPAR activators mag affect BMD by modulating osteoblastic maturation. (C) 2000 Federation of European Biochemical Societies.
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