Journal
ARCHIVES OF INTERNAL MEDICINE
Volume 160, Issue 7, Pages 913-920Publisher
AMER MEDICAL ASSOC
DOI: 10.1001/archinte.160.7.913
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Originally suggested to function mainly in inflammatory situations, recent data have implied important roles for the cyclooxygenase-2 isoenzyme in reproductive biologic processes, renal and neurologic function, and the antithrombotic activities of endothelial cells. As cyclooxygenase-2-specific inhibitors have recently become available as analgesic and anti-inflammatory drugs, a comprehensive view of this rapidly evolving field is necessary to anticipate both the potential therapeutic benefits and toxic effects associated with these agents.
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