Journal
BIOMARKERS IN MEDICINE
Volume 8, Issue 1, Pages 85-94Publisher
FUTURE MEDICINE LTD
DOI: 10.2217/bmm.13.106
Keywords
chronic kidney disease; hypertension; obesity; urine biomarker
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Funding
- Office of Chief Scientist Challenge Grant
- NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES [R01ES017543] Funding Source: NIH RePORTER
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Aims:To determine whether urinary biomarkers of acute kidney injury can be used to monitor the progression of chronic kidney injury in a rat model of hypertension and obesity. Materials & methods: A suite of novel urinary biomarkers were used to track the progression of kidney damage in SHROB and SHR-lean rats. Results: Urinary albumin, NAG, clusterin, osteopontin, RPA-1 and fibrinogen levels were significantly elevated over time and were closely associated with the severity of histopathologically determined nephropathy in both SHROB and SHR-lean rats. Conclusion: Urinary biomarkers, such as albumin, fibrinogen, NAG, clusterin, RPA-1 and osteopontin, may serve as useful tools to track the progression of chronic kidney disease associated with hypertension and obesity.
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