Journal
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
Volume 270, Issue 2, Pages 453-457Publisher
ACADEMIC PRESS INC
DOI: 10.1006/bbrc.2000.2441
Keywords
trichosanthin; ribosome-inactivating protein; receptor-associated protein; the alpha(2)-macroglobulin receptor/LDL receptor related protein; choriocarcinoma cells; receptor binding
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The type-I ribosome-inactivating protein trichosan-thin displays selective cytotoxicity, suggesting specific mechanisms for entry into cells, Here we show that trichosanthin binds specifically to the endocytic receptors LRP and megalin, and that binding as well as uptake into cells is inhibited by the receptor-associated protein (RAP). The results suggest that the known abortifacient and renotoxic actions of trichosanthin are caused by LRP-mediated uptake in trophoblasts and megalin-mediated uptake in proximal tubule epithelial cells, respectively, (C) 2000 Academic Press.
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