Journal
JOURNAL OF IMMUNOLOGY
Volume 164, Issue 8, Pages 3955-3959Publisher
AMER ASSOC IMMUNOLOGISTS
DOI: 10.4049/jimmunol.164.8.3955
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Funding
- NCI NIH HHS [R01CA67416] Funding Source: Medline
- NIAID NIH HHS [R01AI38375] Funding Source: Medline
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To test whether accumulation of naive lymphocytes is sufficient to trigger lymphoid development, we generated mice with islet expression of the chemokine TCA4/SLC, This chemokine is specific for naive lymphocytes and mature dendritic cells (DC) which express the CCR7 receptor. Islets initially developed accumulations of T cells with DC, with scattered B cells at the perimeter. These infiltrates consolidated into organized lymphoid tissue, with high endothelial venules and stromal reticulum, Infiltrate lymphocytes showed a naive CD14(low) CD25(-) CD69(-) phenotype, though half were CD62L negative. When backcrossed to RAG-1 knockout, DC were not recruited. Interestingly, islet lymphoid tissue developed in backcrosses to Ikaros knockout mice despite the absence of normal peripheral nodes. Our results indicate that TCA4/SLC can induce the development and organization of lymphoid tissue through diffential recruitment of T and B lymphocytes and secondary effects on stromal cell development.
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