Studies on the nonmevalonate pathway:: conversion of 4-(cytidine 5′-diphospho)-2-C-methyl-D-erythritol to its 2-phospho derivative by 4-(cytidine 5′-diphospho)-2-C-methyl-D-erythritol kinase

A nonmevalonate pathway intermediate, 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol, is transformed to its 2-phospho-derivative in the presence of ATP by a novel Escherichia coli enzyme, 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase. (C) 2000 Elsevier Science Ltd. All rights reserved.