Journal
ANALYTICA CHIMICA ACTA
Volume 870, Issue -, Pages 8-28Publisher
ELSEVIER
DOI: 10.1016/j.aca.2015.02.016
Keywords
Liquid chromatography-mass spectrometry; Validation; Electrospray; Ionization suppression; Limit of detection; Robustness
Categories
Funding
- Estonian Ministry of Education and Research [IUT20-14, PUT34]
- Estonian Science Foundation [8572]
- EU Regional Development Fund [3.2.1201.13-0020]
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This is the part II of a tutorial review intending to give an overview of the state of the art of method validation in liquid chromatography mass spectrometry (LC-MS) and discuss specific issues that arise with MS (and MS-MS) detection in LC (as opposed to the conventional detectors). The Part II starts with briefly introducing the main quantitation methods and then addresses the performance related to quantification: linearity of signal, sensitivity, precision, trueness, accuracy, stability and measurement uncertainty. The last section is devoted to practical considerations in validation. With every performance characteristic its essence and terminology are addressed, the current status of treating it is reviewed and recommendations are given, how to handle it, specifically in the case of LC-MS methods. (C) 2015 Elsevier B.V. All rights reserved.
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