Journal
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
Volume 376, Issue 2, Pages 433-438Publisher
ELSEVIER SCIENCE INC
DOI: 10.1006/abbi.2000.1735
Keywords
selenoproteins; selenoprotein P; properties; function; regulation
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Selenoprotein P (SeP) is a plasma protein which contains 10 selenocysteine residues per polypeptide. It accounts for more than 50% of the selenium content in rat and human plasma but its function is still not completely understood. However, a function as an extracellular antioxidant seems most probable. A protective function of SeP in human plasma against the potent endotoxin peroxynitrite and phospholipid hydroperoxide reducing activity was demonstrated in vitro. An association of Sep with the vascular endothelium, a prime target of peroxynitrite toxicity, was shown in vivo. Sep of bovine serum acts as a survival-promoting factor in neuronal cell culture. Analysis of the human SeP promoter indicates a transcriptional regulation of SeP by inflammatory mediators. (C) 2000 Academic Press.
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