Journal
BRAIN RESEARCH
Volume 862, Issue 1-2, Pages 253-256Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/S0006-8993(00)02086-2
Keywords
Lewy body; dementia with Lewy bodies; diffuse Lewy body disease; cyclin-dependent kinase 5; immunohistochemistry
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We investigated the cyclin-dependent kinase (Cdk) 5 distribution pattern in diffuse Lewy body disease brains using immunohistochemistry. Cdk5 immunoreactivity was detected in both brainstem-type Lewy bodies (LBs) and cortical LBs. The number of Cdk5-positive LBs was less than that of ubiquitin- or alpha-synuclein-positive LBs, and more than that of phosphorylated neurofilament-positive LBs. Immunoelectron microscopy revealed Cdk5-immunolabeled granulo-filamentous components in LBs and LB-related neurites. These data suggest that Cdk5 may be associated with LB formation. (C) 2000 Elsevier Science B.V. All rights reserved.
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