Journal
BRAIN RESEARCH
Volume 862, Issue 1-2, Pages 266-269Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/S0006-8993(00)02160-0
Keywords
impulsivity; premature response; choice reaction task; AMPA; AMPA receptor antagonist; aniracetam
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The study aimed to ascertain the involvement of central AMPA receptors in impulsive behaviors of aged rats and to examine the effects of aniracetam. Premature response in the two-lever choice reaction task was assessed as an index of impulsivity. Intracerebroventricular injection of 2,3-dihydroxy-6-nitro-7-sulfamoyl-benzo(F)quinoxaline (NBQX), an AMPA receptor antagonist, dose-dependently (10.1-1009 ng/rat) increased only premature response without altering responding speed and choice accuracy 30 min after the injection. Aniracetam (30 mg/kg p.o.), a positive allosteric modulator of AMPA receptors, or AMPA (55.9 ng/rat, co-injected with NBQX) completely restored the NBQX-induced increase in impulsivity. These results indicate that AMPA receptors are tonically involved in the regulation of impulsivity. (C) 2000 Elsevier Science B.V. All rights reserved.
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