Journal
JOURNAL OF CARDIOVASCULAR PHARMACOLOGY
Volume 66, Issue 5, Pages 412-431Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/FJC.0000000000000277
Keywords
atrial fibrillation; antiarrhythmic; ion channel; I-Kur; I-KACh; SK; K-2P
Funding
- European Union [FP7-Health T2-2010-261057]
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There is a clear unmet medical need for new pharmacologic therapies with improved efficacy and safety for the treatment of atrial fibrillation. Considerable research efforts have been undertaken to discover and develop new safe and effective antiarrhythmic drugs that specifically target atrial K+ channels. To realize the full value of these novel atrial-specific therapeutic drug targets, demonstration of clinical efficacy and safety is required for a new breed of atrial-selective antiarrhythmic drugs. The reward for demonstrating this in a pivotal phase III trial, on regulatory approval, will be first-in-class status. This article reviews the development status of new and novel K+ channel inhibitors currently in drug development as atrial-selective antiarrhythmics for the treatment of atrial fibrillation.
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