Journal
BIOMARKERS
Volume 19, Issue 4, Pages 269-274Publisher
TAYLOR & FRANCIS LTD
DOI: 10.3109/1354750X.2014.902101
Keywords
Cancer biomarker; oral cavity cancers; patient survival
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Funding
- Tungs' Taichung MetroHarbor Hospital, Taichung, Taiwan
- [TTMHH-99R0024]
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Context: Mitochondrial DNA (mtDNA) copy number correlates with tumor pathology in some cancers. Objective: To investigate mtDNA copy number in head and neck cancer (HNC). Materials and methods: mtDNA copy number was determined and compared between HNC patients and malignancy-free controls. Results: The mtDNA copy number was significantly higher in HNC patients, increased with cancer progression and correlated negatively with patient survival. Discussion: mtDNA copy number appears to be associated with HNC stage and survival, but confirmation requires similar studies in larger cohorts. Conclusion: Studies to establish the nature of the relationship between mtDNA copy number and HNC are warranted.
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