Journal
BIOMARKERS
Volume 19, Issue 1, Pages 34-42Publisher
INFORMA HEALTHCARE
DOI: 10.3109/1354750X.2013.865275
Keywords
Circulating tumor cells; MAGE; ovarian cancer; surveillance marker
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Funding
- National Nature Science Foundation of China [81001178]
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Ovarian cancer is a leading cause of death among gynecologic malignancies. In this study, we reported the expression of melanoma-associated antigens A (MAGE-A) genes in peripheral blood from 80 patients with ovarian cancer and 30 healthy donors. MAGE-As expression was associated with the factors indicating poor prognosis. The expressions of MAGE-As and each individual MAGE-A genes were also associated with low overall survival of patients with ovarian cancer. Our results suggested MAGE-A genes may have the potential to be surveillance markers for the detection of circulating tumor cells and represent a poor prognosis for patients with ovarian cancer.
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