Journal
BIOMARKERS
Volume 18, Issue 2, Pages 165-173Publisher
TAYLOR & FRANCIS LTD
DOI: 10.3109/1354750X.2012.762807
Keywords
Biomarkers; diet; DNA adducts; genotyping; metabolism; polycyclic aromatic hydrocarbons; polymorphism
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Funding
- EU DG Research [FOOD-CT-2003-505609]
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Exposure of the general population to polycyclic aromatic hydrocarbons (PAH) is ubiquitous. The aim of this study was to analyze biomarkers associated with the uptake of PAH in 428 non-smoking women from Lodz (Poland), Viterbo (Italy), Belgrade (Serbia) and from the Pancevo area, where the petrochemical complex was destroyed by the air raids in 1999. Urinary excretion of PAH metabolites was lowest in Italian women, intermediary for Serbian and highest in Polish women, who predominantly excreted hydroxy phenanthrenes as metabolites of phenanthrene. Bulky DNA adduct levels were highest in Italian and Polish women. Genotype or PAH ambient air levels could not explain the dissimilarities between the study groups with respect to biomarker patterns, which probably reflected differences in life style-associated factors.
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