Journal
BIOMARKERS
Volume 18, Issue 8, Pages 673-678Publisher
TAYLOR & FRANCIS LTD
DOI: 10.3109/1354750X.2013.845609
Keywords
Biomarker; dietary exposure; maternal exposure; ochratoxin A; OTA; pregnancy
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Funding
- Faculty of Science, University Hradec Kralove, Czech Republic [2119/2012]
- Czech Ministry of Health (IGA MZ CR) [12051-3/2011]
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The mycotoxin ochratoxin A (OTA) can elicit a wide range of toxic properties including embryotoxicity and teratogenicity. OTA crosses the placenta at early gestation rather than in late gestation, maternal OTA exposure may represent a risk for the developing fetus. The study focuses on the assessment of OTA intake of pregnant women (aged 19-40 years) in the first trimester of pregnancy by means OTA levels in 100 blood serum samples by high-performance liquid chromotography with fluorescence detection (HPLC-FD) method and comparison with dietary OTA exposure in pregnant women. Of all, 96% tested serum samples were positive with values ranging from 0.1 to 0.35 mu g/l with a mean value of 0.15 mu g/l.
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