Journal
BIOMARKERS
Volume 17, Issue 6, Pages 483-489Publisher
INFORMA HEALTHCARE
DOI: 10.3109/1354750X.2012.691553
Keywords
Biomarker; exposome; metabolomics; proteomics; EWAS; discovery
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Funding
- NIEHS NIH HHS [U54 ES016115, P42 ES004705, U54ES016115] Funding Source: Medline
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The exposome concept promotes use of omic tools for discovering biomarkers of exposure and biomarkers of disease in studies of diseased and healthy populations. A two-stage scheme is presented for profiling omic features in serum to discover molecular biomarkers and then for applying these biomarkers in follow-up studies. The initial component, referred to as an exposome-wide-association study (EWAS), employs metabolomics and proteomics to interrogate the serum exposome and, ultimately, to identify, validate and differentiate biomarkers of exposure and biomarkers of disease. Follow-up studies employ knowledge-driven designs to explore disease causality, prevention, diagnosis, prognosis and treatment.
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