Journal
BIOMARKERS
Volume 17, Issue 5, Pages 435-440Publisher
TAYLOR & FRANCIS LTD
DOI: 10.3109/1354750X.2012.680611
Keywords
Cytokines; inflammation; microRNA; plasmas; smoking-related interstitial fibrosis
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Funding
- China National Tobacco Corporation [110200701007]
- Chongqing Research Program [06-1-173]
- Science & Technology Department of Sichuan Province [2010JY0154]
- Post-Doctor Research Program of China Tobacco Chuanyu Industrial
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Numerous efforts have been made to indentify reliable and predictive biomarkers to detect the early signs of smoking-induced lung disease. Using 6-month cigarette smoking in mice, we have established smoking-related interstitial fibrosis (SRIF). Microarray analyses and cytokine/chemokine biomarker measurements were made to select circulating microRNAs (miRNAs) biomarkers. We have demonstrated that specific miRNAs species (miR-125b-5p, miR-128, miR-30e, and miR-20b) were significantly changed, both in the lung tissue and in plasma, and exhibited mainstream (MS) exposure duration-dependent pathological changes in the lung. These findings suggested a potential use of specific circulating miRNAs as sensitive and informative biomarkers for smoking-induced lung disease.
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