Journal
BIOMARKERS
Volume 17, Issue 8, Pages 738-744Publisher
TAYLOR & FRANCIS LTD
DOI: 10.3109/1354750X.2012.727027
Keywords
Stroke; osteoprotegerin; functional outcome; stroke severity
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Funding
- Korea Healthcare Technology Research and Development Project, Ministry for Health, Welfare, and Family Affairs, Republic of Korea [A060171, A085136]
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Osteoprotegerin (OPG) is known to regulate processes involved in vascular injury and inflammation. We investigated the relationship between plasma OPG levels and stroke subtype, stroke severity at admission and functional outcome at 3 months in 172 patients with acute ischaemic stroke. Patients with large artery atherosclerosis and those with multiple causes had higher plasma OPG levels than patients with lacune. Increased plasma OPG levels were independently associated with more severe stroke and poor functional outcome. These results suggest pleiotropic roles of OPG in mediating atherosclerosis and ischaemic brain injury. OPG is a potential biomarker for predicting neurologic outcome in stroke.
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