Journal
BIOMARKERS
Volume 17, Issue 8, Pages 750-757Publisher
INFORMA HEALTHCARE
DOI: 10.3109/1354750X.2012.727030
Keywords
Gold nanoparticles; intravenous injection; miRNA microarrays; blood biomarkers; health effects
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Funding
- National University of Singapore Environmental Research Institute
- King Saud University
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Context: Increased use of engineered nanoparticles may result in exposure of workers and consumers, making them a health concern. Objective: To identify potential blood miRNA biomarkers after intravenous gold nanoparticle (AuNP) exposure. Materials and methods: miRNA microarray analysis was carried out on blood of rats at 1 week and 2 months after injection. Results: Many up-and downregulated miRNAs were detected. Of these, rno-miR-298 was confirmed to be increased at 1 week postinjection by reverse transcription-PCR (RT-PCR). Discussion and conclusion: Blood miRNAs could be useful as biomarkers for exposure to nanoparticles. miR-298 regulates beta-amyloid (A beta) precursor protein-converting enzyme-1 (BACE1) in Alzheimer's disease.
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