Journal
NEUROSCIENCE LETTERS
Volume 284, Issue 1-2, Pages 33-36Publisher
ELSEVIER SCI IRELAND LTD
DOI: 10.1016/S0304-3940(00)01004-1
Keywords
frequenin; neuromuscular junction; muscle spindle; nerve; denervation
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Funding
- NINDS NIH HHS [NS33320] Funding Source: Medline
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Frequenin is a calcium binding protein previously implicated in the regulation of neurotransmission in Drosophila and Xenopus. We have used the frog (Rana pipiens) to study the localization and regulation of expression of frequenin-like molecules in the vertebrate peripheral nervous system. Affinity purified antibodies to frequenin recognize molecules in the neuromuscular junction, axons in the peripheral nerve, and neuronal processes in muscle spindles. Western blots of endplate regions, peripheral nerve, and brain, resulted in the labelling of a single 24 kDa band, which is the expected size for frequenin. These results suggest that frequenin expression is high in the frog peripheral nervous system, and may reflect a function for frequenin in synaptic transmission in vertebrates. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.
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